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butabarbital will lessen the level or impact of norgestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Moderate CYP3A4 inducers may well lower progestin focus; contemplate use of added barrier strategiesbutabarbital will lower the level or effect of etonogestrel by affecting hepatic/intestinal enzyme CYP